For citation:
Zakharov D. G., Kasatkin D. V., Kirillov S. Y., Kuznetsov A. S. Feature of simultaneous influence of excitatory synaptic currents on a neuron with differential responses. Izvestiya VUZ. Applied Nonlinear Dynamics, 2015, vol. 23, iss. 2, pp. 47-56. DOI: 10.18500/0869-6632-2015-23-2-47-56
Feature of simultaneous influence of excitatory synaptic currents on a neuron with differential responses
The simultaneous influence of excitatory synaptic stimuli (the tonic AMPA and NMDA currents) on the neuron model with response differentiation is studied. It is shown that different types of neuron activity (rest state, low frequency or high frequency firing) are observed depending on the conductance of the AMPA and NMDA receptors. It is found that for the certain parameters values if both types of receptors are activated simultaneously, it is possible to obtain maximal frequency to be approximately 20% greater than that with the NMDA current alone. Thus, we confirm the major role of NMDA receptors in the appearance of high-frequency firing and conclude that AMPAR activation may further significantly increase the frequency. The dynamical mechanism of such frequency growth is explained in the framework of phase plain evolution.
- Hajos M., Gartside S.E., Villa A.E., and Sharp T. Evidence for a repetitive (burst) firing pattern in a sub-population of 5-hydroxytryptamine neurons in the dorsal and median raphe nuclei of the rat // Neuroscience. 1995. Vol. 69, No 1. P. 189.
- Muntoni A.L., Pillolla G., Melis M., Perra S., Gessa G.L., and Pistis M. Cannabinoids modulate spontaneous neuronal activity and evoked inhibition of locus coeruleus noradrenergic neurons // Eur J Neurosci. 2006. Vol. 23, No 9. P. 2385.
- Wilson C.J. and Callaway J.C. A coupled oscillator model of the dopaminergic neuron of the substantia nigra // J. Neurophysiol. 2000. Vol. 83. P. 3084.
- Hajos M., Sharp T., Newberry N.R. Intracellular recordings from burst-firing presumed serotonergic neurones in the rat dorsal raphe nucleus in vivo // Brain Res. 1996. Vol. 737, No 1–2. P. 308.
- Richards C.D., Shiroyama T. and Kitai S.T. Electrophysiological and immunocytochemical characteristics of GABA and dopamine neurons in the substantia nigra of the rat // Neuroscience. 1997. Vol. 80. P. 545.
- Overton P., Clark D. Burst firing in midbrain dopaminergic neurons // Brain Res. Reviews. 1997. Vol. 25. P. 312.
- Morikawa H., Khodakhah K., Williams J. Two intracellular pathways medicate metabotropic glutamate receptor-induced Ca2+ mobilization in dopamine neurons // J. Neuroscience. 2003. Vol. 23. P. 149.
- Deister C.A., Teagarden M.A., Wilson C.J., Paladini C.A. An intrinsic neuronal oscillator underlies dopaminergic neuron bursting // J Neurosci. 2009. Vol. 29. P. 15888.
- Kuznetsov A.S., Kopell N.J., and Wilson C.J. Transient high-frequency firing in a coupled-oscillator model of the mesencephalic dopaminergic neuron // J. Neuro-physiol. 2006. Vol. 95. P. 932.
- Oster A., Gutkin B.S. A reduced model of DA neuronal dynamics that displays quiescence, tonic firing and bursting // J. Physiol. Paris. 2011. Vol. 105, No 1–3. P. 53.
- Ha J., Kuznetsov A. Interaction of NMDA Receptor and Pacemaking Mechanisms in the Midbrain Dopaminergic Neuron // PLoS ONE. 2013. Vol. 8, No 7. e69984.
- Zakharov D.G., Kuznetsov A.S. A differentiation mechanism of neuron response on the excitable external signals // JEPT Letters. 2012. Vol. 95, No 11. P. 598.
- Zakharov D.G., Kuznetsov A.S. A minimal model for a slow pacemaking neuron // Chaos, Solitons & Fractals. 2012. Vol. 45. P. 640.
- Saal D., et al. Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons // Neuron. 2003. Vol. 37, No 4. P. 557.
- FitzHugh R. Impulses and physiological states in theoretical models of nerve membrane // Biophysical J. 1961. Vol. 1. P. 445.
- Li Y.-X., Bertram R., and Rinzel J. Modeling N-methyl-D-aspartate-induced bursting in dopamine neurons // Neuroscience. 1996. Vol. 71. P. 397.
- Christoffersen C.L., and Meltzer L.T. Evidence for n-methyl-d-aspartate and ampa subtypes of the glutamate-receptor on substantia-nigra dopamine neurons – possible preferential role for n-methyl-d-aspartate receptors // Neuroscience. 1995. Vol. 67, No 2. P. 373.
- 1962 reads