ISSN 0869-6632 (Print)
ISSN 2542-1905 (Online)

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Anishchenko T. G., Glushkovskaya-Semyachkina O. V. Normalized entropy as an additional criteria of cardiovascular responsivity to nerve regulation blockade in rats of both sexes. Izvestiya VUZ. Applied Nonlinear Dynamics, 2003, vol. 11, iss. 2, pp. 116-122. DOI: 10.18500/0869-6632-2003-11-2-116-122

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Normalized entropy as an additional criteria of cardiovascular responsivity to nerve regulation blockade in rats of both sexes

Anishchenko Tatyana Grigorievna, Saratov State University

In experiments оn rats оf both sexes wе investigated the sensitivity оf cardiovascular system to sympathetic and parasympathetic blockade using physiological parameters - heart rate, arterial pressure and a new criteria of complexity of blood pressure dynamics - normalized entropy. The results showed that in females compared with males cardiovascular system is more sensitive to pharmacological agents blocking the sympathetic and parasympathetic influences. These facts suggest that autonomic nerves regulation of cardiovascular system is more pronounced in females than in males. The normalized entropy was demonstrated to be more sensitive criteria of changes in cardiovascular system induced by pharmacological agents. Our data suggested that new measure of the complexity degree of blood pressure dynamics may be useful for evaluation оf cardiovascular response to different external and internal perturbations.

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The research was partially supported by a CRDF grant (REC-006) and a grant from the Russian Ministry of Education RD 02 -1.4-261.
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