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Meglinsky I. V., Boas D. A., Yodh A. G., Chance B., Tuchin V. V. Development of correlation of laser eradiation intensity fluctuations techniques for non-invasive monitoring and measuring of blood flow changes. Izvestiya VUZ. Applied Nonlinear Dynamics, 1996, vol. 4, iss. 6, pp. 72-81.

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Russian
Heading: 
Applied Problems of Nonlinear Oscillation and Wave Theory
Article type: 
Article
UDC: 
535.36

Development of correlation of laser eradiation intensity fluctuations techniques for non-invasive monitoring and measuring of blood flow changes

Autors: 
Meglinsky Igor Vladislavovich, Saratov State University
Boas David Alan, Tufts University
Yodh Arjen G., Pennsylvania State University
Chance Britton, Pennsylvania State University
Tuchin Valerij Viktorovich, Saratov State University
Abstract: 

We have non-invasively measured in vivo blood flow changes using photon correlation spectroscopy (Diffusing Wave Correlation Techniques) with а simple correlation diffusion model to study and quantify blood flow in the human arm during cuff ischemia. The method utilizes the Doppler broadening of light that arises in a multiply scattering dynamic media, and is also responsive to changes in absorption and scattering coefficients. Our measurements clearly show blood flow changes with cuff pressures, including the hyperemic overshoot after cuff release, that qualitatively agree with the physiological behavior of the cardiovascular system. In this article, we present method, results and discuss the clinical relevance of our findings.

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Reference: 
  1. Priezzhev AV, Tuchin VV, Shubochkin LP. Laser Diagnostics in Biology and Medicine. М.: Nauka; 1989. 240 p.
  2. Tuchin VV, editor. Selected Papers on Tissue Optics. Applications in Medical Diagnostics and Therapy. Bellingham: SPIE Publ.; 1994. 700 p.
  3. Romanovskii YuМ, Teplov VA. The physical bases of cell movement. The mechanisms of self-organisation of amoeboid motility. Phys. Usp. 1995;38(5):521-542. DOI: 10.1070/pu1995v038n05abeh000086.
  4. Zimnyakov DА, Tuchin VV, Utz SR. Study of statistical properties of partially developed speck fields in relation to the diagnosis of structural changes in human skin. Opt. Spectroscopy. 1994;76(5):838-844.
  5. Kolinko VG, Priezzhev АV. Application of the time-gating technique to laser Doppler tomography of biological tissues. Proc. SPIE. 1995;2626:158-174. DOI: 10.1117/12.228662.
  6. Tuchin VV. CIS Selected papers. Coherence-Domain Methods in Biomedical Optics. Vol. 2732. Bellingham: SPIE Publ.; 1996.
  7. Shepherd AP, Oberg PA. Lasers Doppler Blood Flowmetry. N.Y.: Springer; 1990. 396 p.
  8. Priezzhev AV, Romanovskii YuМ. Laser Doppler spectroscopy and its applications in biology. Sov. J. Quantum Electron. 1978;8(10):1260-1263. DOI: 10.1070/QE1978v008n10ABEH011049.
  9. Silva J, Intaglietita M. The correlation of photometric signals derived from in vivo red blood cell flow in microvessels. Microvasc. Res. 1974;7(2):156-169. DOI: 10.1016/0026-2862(74)90002-8.
  10. Tanaka T, Benedek GB. Measurement of the velocity of blood flow (in vivo) using а fiber optic catheter and optical mixing spectroscopy. Appl. Opt. 1975;14(1):189-196. DOI: 10.1364/AO.14.000189.
  11. Gush RJ, King ТА, Jayson МIМ. Aspects of laser light scattering from skin tissue with application to laser Doppler blood flow measurement. Phys. Med. Biol. 1984;29(12):1463-1476. DOI: 10.1088/0031-9155/29/12/001.
  12. Bonner R, Nossal R. Model of laser Doppler measurements of blood flow in tissue. Appl. Opt. 1981;20(12):2097-2107. DOI: 10.1364/AO.20.002097.
  13. Aizu У, Asakura T, Ogino K, Sugita Т. Evaluation of flow volume in а capillary using dynamic laser speckles based on the photon correlation. Opt. Commun. 1990;80(1):1-6. DOI: 10.1016/0030-4018(90)90495-F.
  14. Lebedev АD, Levchuk YuN, Lomakin AV, Noskin VA. Laser Correlation Spectroscopy in Biology. Kiev: Naukova dumka; 1987. 255 p.
  15. Cummins HZ, Pike ER. Photon Correlation and Light Beating Spectroscopy. N.Y.: Plenum Press; 1973. 584 p.
  16. Brown W. Dynamic Light Scattering. The method and some applications. Охford: Clarendon Press; 1993. 752 p.
  17. Ulyanov SS, Zimnyakov DA, Tuchin VV. Fundamentals and applications of dynamic speckles induced by focused laser beam scattering. Optical Engineering. 1994;33(10):3189-3201. DOI: 10.1117/12.178896.
  18. Ulyanov SS. Features of the Doppler effect during diffraction of focussed Gaussian beams in randomly moving heterogeneous media. Bulletin of the Russian Academy of Sciences: Physics. 1995;59(6):151-155.
  19. Ackerson BJ, Dougherty RL, Reguigui NM, Nobbman U. Correlation Transfer: Application of Radiative Transfer Solution Methods to Photon Correlation Problems. J. Thermophys. Heat Transfer. 1992;6(4):577-588. DOI: 10.2514/3.11537.
  20. Fuller GG, Rallison JM, Schmidt RL, Leal LG. The measurement of velocity gradients in laminar flow by homodyne light-scattering spectroscopy. J. Fluid Mech. 1980;100(3):555-575. DOI: 10.1017/S0022112080001280.
  21. Pine DJ, Weitz DA, Zhu JX, Hebolzheimer Е. Diffusing-Wave Spectroscopy: dynamic light scattering in the multiple scattering limit. J. Phys. France. 1990;51:2101-2127. DOI: 10.1051/jphys:0199000510180210100.
  22. Bicout D, Maynard R. Diffusing wave spectroscopy in inhomogeneous flows. Physica A. 1993;199(3-4):387-411. DOI: 10.1016/0378-4371(93)90056-A.
  23. Weitz DA, Pine DJ. Diffusing-Wave Spectroscopy. In: Brown W, editor. Dynamic Light Scattering. The method and some applications. Oxford: Clarendon Press; 1993. Р. 653.
  24. Boas DA, Meglinsky LY, Zemany L, Cambell LE, Chance B, Yodh AG. Diffusion of Temporal Field Correlation with Selected Applications. In: Tuchin VV, editor. SIC Selected Papers: Coherence Domain Methods in Biomedical Optics. Vol. 2732. Bellingham: SPIE; 1996. P. 34.
  25. Patterson MS, Chance B, Wilson BC. Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. Appl. Opt. 1989;28(12):2331-2336. DOI: 10.1364/AO.28.002331.
  26. Xue J-Z, Pine DJ, Milner ST, Wu X-L, Chaikin PM. Nonergodicity and light scattering from polymer gels. Phys. Rev. А. 1992;46(10):6550-6563. DOI: 10.1103/physreva.46.6550.
  27. Boas DA, Cambell LE, Yodh AG. Scattering and imaging with diffusing temporal field correlations. Phys. Rev. Lett. 1995;75(9):1855-1858. DOI: 10.1103/PhysRevLett.75.1855.
  28. Boas DA, Cambell LE, Yodh AG. Fluctuation Imaging. Proc. SPIE. 1995;2389:220-227. DOI: 10.1117/12.209970.
  29. Wu X-L, Pine DJ, Chaikin PM, Huang JS, Weitz DA. Diffusing-wave spectroscopy in а shear flow. JOSA В. 1990;7(1):15-20. DOI: 10.1364/JOSAB.7.000015.
  30. Ricka J. Dynamic light scattering with single-mode and multimode receivers. Аррl. Opt. 1993;32(15):2860-2875. DOI: 10.1364/AO.32.002860.
  31. Chance B, Nioka S, Kent J, McCully K, Fountain M, Greenfield R, Holtom G. Time resolved spectroscopy of hemoglobin and myoglobin in resting and ischemic muscle. Anal. Biochem. 1988;174(2):698-707. DOI: 10.1016/0003-2697(88)90076-0.
  32. Chance B, Dait M, Zhang C, Hamaoka T, Hagerman Е. Recovery from exercise-induced desaturation in the quadriceps muscles of elite competitive rowers. Am. J. Physiol. 1992;262(3Pt1):C766-C775. DOI: 10.1152/ajpcell.1992.262.3.C766.
  33. Zimnyakov DA, Tuchin VV, Utz SR, Mishin AA. Far-zone speckle statistics study in applications to biotissue structure imaging. Proc. SPIE. 1995;2390:170. DOI: 10.1117/12.205996.
Received: 
04.09.1996
Accepted: 
30.12.1996
Published: 
08.04.1997
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