For citation:
Shuvalova E. V., Kubasov A. A., Romanovsky Y. M., Chikishev A. Y. Dynamics of proton transfer in ∝-chymotrypsin enzyme active site. Izvestiya VUZ. Applied Nonlinear Dynamics, 2000, vol. 8, iss. 5, pp. 23-35. DOI: 10.18500/0869-6632-2000-8-5-23-35
Dynamics of proton transfer in ∝-chymotrypsin enzyme active site
The ∝-chymotrypsin enzyme that splits peptide chains in е process of digestion is considered. The proton transfer in one of hydrogen bonds of catalytic group of enzyme
active site is process, which leads to peptide bond splitting. Such process in potential field of enzyme active site is studied. It is demonstrated а! energy surface profile of active
site is changed after substrate fixing to facilitate a proton transfer. The enzyme active site field fluctuating by the influence of random thermal oscillation of environment atoms, the proton transfer in nonstationary profile is accounted. Fluctuations of potential field are described by both of white and coloured noise. The influence amplitude and frequency of coloured noise, also asymmetry between depth of е double—well potential are шvestigated. It is showed that in addition to tunnelling in а nonstationary potential the non-coherent, dynamical irreversible process of the proton transfer exists. That is called because affect of the noise to the potential form.
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