ISSN 0869-6632 (Print)
ISSN 2542-1905 (Online)

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Parin S. B., Chernova M. A., Polevaia S. A. Adaptive control signals of a mismatch in cognitive processes: the role of the endogenous opioid system. Izvestiya VUZ. Applied Nonlinear Dynamics, 2011, vol. 19, iss. 6, pp. 65-74. DOI: 10.18500/0869-6632-2011-19-6-65-74

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004.8; 004.93’1; 004.932; 004.94; 159.9; 612.821

Adaptive control signals of a mismatch in cognitive processes: the role of the endogenous opioid system

Parin Sergej Borisovich, Lobachevsky State University of Nizhny Novgorod
Chernova Marija Andreevna, Lobachevsky State University of Nizhny Novgorod
Polevaia Sofia Alexandrovna, Lobachevsky State University of Nizhny Novgorod

In the work we consider the classic cyclic schemes for the construction of cognitive processes. Based on neurobiological data we indicate the need to introduce a special mechanism for adaptive control signals of a mismatch in cognitive processes at the stage preceeding the decision point. Endogenous opioid system can be considered one of the major neurochemical candidates for such «breakers». This system provides the suppression of signals about a mismatch between current and target states of the cognitive system. 

  1. Kawamura K, Parin SB, Polevaya SA, Yakhno VG. Possibility of building simulators of sensory signals awareness: hierarchy of «recognition cells», neuroarchitecture, psychophysical data. In: Scientific Session of MEPHI – 2008. X All-Russian Scientific and Technical Conference «Neuroinformatics – 2008»: Lectures on Neuroinformatics. Part 1. Moscow: MEPHI; 2008. P. 23–57 (in Russian).
  2. Anokhin PK. Biology and Neurophysiology of the Conditioned Reflex and Its Role in Adaptive Behavior. Pergamon; 1974. 591 p.
  3. Yakhno VG. Dynamics of neuron-like models and processes of consciousness. In: VIII All-Russian scientific and technical conference «Neuroinformatics – 2006»: Lectures on Neuroinformatics. Moscow: MEPHI; 2006. P. 88–111 (in Russian).
  4. Pert CB, Snyder SH. Opiate receptor: Demonstration in nervous tissue. Science. 1973;179(4077):1011–1014. DOI: 10.1126/science.179.4077.1011.
  5. Terenius L. Stereospecific interaction between narcotic analgesics and synaptic plasma membrane fraction of rat cerebral cortex. Acts Pharmacol. Toxicol. 1973;32(3):317–320. DOI: 10.1111/j.1600-0773.1973.tb01477.x.
  6. Hughes J, Smith TW, Kosterlitz HW, Fothergill UA, Morgan BA, Morris HR. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature. 1975;258(5536):577–579. DOI: 10.1038/258577a0.
  7. Terenius L, Wahlstrom A. Morphine-like ligand for opiate receptors in human CSF. Life Sciences. 1975;16(12):1759–1764. DOI: 10.1016/0024-3205(75)90269-6.
  8. Teschemacher H, Opheim KE, Cox BM, Goldstein A. A peptide-like substance from pituitary that acts like morphine. Life Sciences. 1975;16(12):1771–1775. DOI: 10.1016/0024-3205(75)90271-4.
  9. Schmidt RF, Thews G. Physiologie des Menschen. Berlin, Heidelberg, New-York, London, Paris, Tokyo: Springer-Verlag; 1987. 886 s. (in German).
  10. Parin SB. Humans and animals in extreme situations: neurochemistry mechanisms, evolutionary aspect. NSU Bulletin. 2008;2(2):118–135 (in Russian).
  11. Olson GA, Olson RD, Vaccarino AL, Kastin AJ. Endogenous opiates: 1997. Peptides. 1998;19(10):1791–1843. DOI: 10.1016/S0196-9781(98)00137-5.
  12. Bodnar RJ. Endogenous opiates and behavior: 2007. Peptides. 2008;29(12):2292–2375. DOI: 10.1016/j.peptides.2008.09.007.
  13. Yakhno VG, Polevaya SA, Parin SB. The basic architecture of the system describing the neurobiological mechanisms of awareness of sensory signals. In: Cognitive Research. Vol. 4. Moscow: Publishing House of the Institute of Psychology of the RAS; 2010. P. 273 (in Russian).
  14. Golanov EV, Kalyuzhny LV, Parin SB, Sudakov KV. A Method of Treating Shock. USSR Author's Certificate No. 1138165 dated 10.08.84 (Priority from 05.07.80) (in Russian).
  15. Golanov EV, Fufacheva AA, Cherkovich GM, Parin SB. Influence of ligands of opiate receptors on emotiogenic reactions of the cardiovascular system in lower primates. Bulletin of Experimental Biology and Medicine. 1987;103(4):424–427 (in Russian).
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