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ISSN 2542-1905 (Online)

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Language: 
Russian
Heading: 
Nonlinear Dynamics and Neuroscience
Article type: 
Article
UDC: 
530.182
DOI: 
10.18500/0869-6632-003125
EDN: 
BIUYWZ

Effects of the dynamics of noise-induced calcium signals in a biophysical model of the astrocytic process

Autors: 
Ermolaeva Anastasia Viktorovna, Lobachevsky State University of Nizhny Novgorod
Kastalskiy Innokentiy A., Lobachevsky State University of Nizhny Novgorod
Kazantsev Viktor Borisovich, Institute of Applied Physics of the Russian Academy of Sciences
Gordleeva Susanna Yurevna, Lobachevsky State University of Nizhny Novgorod
Abstract: 

The purpose of this work is to study the effects of spatio-temporal dynamics of spontaneous calcium signaling in the morphological structure of an astrocyte at the subcellular level using biophysical mathematical modeling methods.

Methods. This work proposes a biophysical multicompartmental model of noise-induced calcium dynamics in the astrocytic process. The model describes the process of generation of spontaneous Ca2+ signals induced by the stochastic activation of voltage-dependent Ca2+ channels on the plasma membrane of the astrocyte. The model allows us to study the dynamics of the propagation of spontaneous local Ca2+ signals and the mechanisms of formation of spatial Ca2+ patterns in the astrocytic process.

Results. The developed model enables studying the influence of morphology and intracellular biophysical mechanisms on the characteristics of spontaneous noise-induced Ca2+ signaling in the astrocytic process. The parameter ranges at which the model qualitatively reproduces the spontaneous Ca2+ activity at the subcellular level observed in experimental studies have been specified. The characteristics of noise-induced Ca2+ patterns propagating along the process were investigated, depending on the internal structure of the process, its geometry, and the steady state concentration of inositol 1,4,5-triphosphate molecules.

Key words: 
astrocytic process
compartment
calcium signal
inositol 1
4
5-triphosphate
anomalous diffusion
Acknowledgments: 
This work was supported in part by the Ministry of Science and Higher Education of the Russian Federation according to research project No. FSWR-2023-0029 (conceptual model of astrocytic process and model dynamics) and in part by RFBR research project No. 20-32-90151 (development of software for numerical simulations and data analysis).
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Received: 
01.03.2024
Accepted: 
21.05.2024
Available online: 
24.09.2024
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