ISSN 0869-6632 (Print)
ISSN 2542-1905 (Online)

For citation:

Zakharov D. G., Kasatkin D. V., Kirillov S. Y., Kuznetsov A. S. Feature of simultaneous influence of excitatory synaptic currents on a neuron with differential responses. Izvestiya VUZ. Applied Nonlinear Dynamics, 2015, vol. 23, iss. 2, pp. 47-56. DOI: 10.18500/0869-6632-2015-23-2-47-56

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Language: 
Russian
Heading: 
Nonlinear Dynamics and Neuroscience
Article type: 
Article
UDC: 
621.373.1
DOI: 
10.18500/0869-6632-2015-23-2-47-56

Feature of simultaneous influence of excitatory synaptic currents on a neuron with differential responses

Autors: 
Zakharov Denis Gennadevich, National Research University "Higher School of Economics"
Kasatkin Dmitry Vladimirovich, Institute of Applied Physics of the Russian Academy of Sciences
Kirillov Sergej Yu., Institute of Applied Physics of the Russian Academy of Sciences
Kuznetsov Aleksej Sergeevich, Saratov State University
Abstract: 

The simultaneous influence of excitatory synaptic stimuli (the tonic AMPA and NMDA currents) on the neuron model with response differentiation is studied. It is shown that different types of neuron activity (rest state, low frequency or high frequency firing) are observed depending on the conductance of the AMPA and NMDA receptors. It is found that for the certain parameters values if both types of receptors are activated simultaneously, it is possible to obtain maximal frequency to be approximately 20% greater than that with the NMDA current alone. Thus, we confirm the major role of NMDA receptors in the appearance of high-frequency firing and conclude that AMPAR activation may further significantly increase the frequency. The dynamical mechanism of such frequency growth is explained in the framework of phase plain evolution. 

Key words: 
Neuron
excitatory synaptic current
AMPA
NMDA
response differentiation
Reference: 
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Received: 
03.04.2015
Accepted: 
20.05.2015
Published: 
31.07.2015
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