ISSN 0869-6632 (Print)
ISSN 2542-1905 (Online)

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Semenova N. И., Tuchin V. V. Impact of osmotic pressure on cancer cells in a three-dimensional cellular lattice and cell spheroid. Izvestiya VUZ. Applied Nonlinear Dynamics, 2021, vol. 29, iss. 4, pp. 559-570. DOI: 10.18500/0869-6632-2021-29-4-559-570

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Impact of osmotic pressure on cancer cells in a three-dimensional cellular lattice and cell spheroid

Semenova Nadezhda Игоревна, Saratov State University
Tuchin Valerij Viktorovich, Saratov State University

The purpose of this work is to study the peculiarities of external influence, namely osmotic pressure, on cancer cells. Methods. For this purpose, spatially distributed systems describing the dynamics of a three-dimensional cell lattice, a cell spheroid, and a cell surface have been considered. The studied models are based on the basic principles of hydrodynamics, and their numerical simulation has been performed using a modified Euler method. Results. The paper proposes three-dimensional models to study the dynamics of cancer cells in the epidermal layer of the skin; the models include the possibility of adding additional pressure and changing it with a single parameter. It is shown that it is possible to achieve a slowdown of cancer cell growth in all considered models at certain values of osmotic pressure.

This study is supported by the grant of RF Government No. 14.Z50.31.0044
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