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Sosnovtseva O. V., Pavlov A. N., Mosekilde E., Holstein-Rathlou N. Synchronization phenomena in multimode dynamics of coupled nephrons. Izvestiya VUZ. Applied Nonlinear Dynamics, 2003, vol. 11, iss. 3, pp. 133-147. DOI: 10.18500/0869-6632-2003-11-3-133-147

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Synchronization phenomena in multimode dynamics of coupled nephrons

Sosnovtseva Olga Vladimirovna, Danmarks Tekniske Universitet
Pavlov Aleksej Nikolaevich, Saratov State University
Mosekilde Erik, Technical University of Denmark
Holstein-Rathlou Niels H., Panum Institute

The individual functional unit оf the kidney (the nephron) displays oscillations in its regulation оf the incoming blood flow аt two different time scales: fast oscillations associated with а myogenic dynamics of the afferent arteriole, and slower oscillations arising from а delay in the tubuloglomerular feedback. The paper investigates the intra- and inter-nephron interactions of these two modes. Besides full synchronization, both wavelet analyses of experimental data and numerical simulations of a detailed physiological model reveal the occurrence of а partial entrainment in which neighboring nephrons attain а state оf synchronization with respect to their slow dynamics, but the fast dynamics remain desynchronized.

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The research described in this publication was made possible to part by Award N. SR-006-X1 of the U.S.Civilian Research & Development Foundation for the Independent States of the Former Soviet Union (CRDF). A.P. acknowledges support from RF Minobr аnd CRDF (grant Y1-P-06-06). This work was also partly supported by INTAS grant (01-2061) and RFBR (01-02-16709).
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