ISSN 0869-6632 (Print)
ISSN 2542-1905 (Online)

For citation:

Sosnovtseva O. V., Pavlov A. N., Mosekilde E., Holstein-Rathlou N. Synchronization phenomena in multimode dynamics of coupled nephrons. Izvestiya VUZ. Applied Nonlinear Dynamics, 2003, vol. 11, iss. 3, pp. 133-147. DOI: 10.18500/0869-6632-2003-11-3-133-147

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English
Heading: 
Applied Problems of Nonlinear Oscillation and Wave Theory
Article type: 
Article
UDC: 
519.6:577.359
DOI: 
10.18500/0869-6632-2003-11-3-133-147

Synchronization phenomena in multimode dynamics of coupled nephrons

Autors: 
Sosnovtseva Olga Vladimirovna, Danmarks Tekniske Universitet
Pavlov Aleksej Nikolaevich, Saratov State University
Mosekilde Erik, Technical University of Denmark
Holstein-Rathlou Niels H., Panum Institute
Abstract: 

The individual functional unit оf the kidney (the nephron) displays oscillations in its regulation оf the incoming blood flow аt two different time scales: fast oscillations associated with а myogenic dynamics of the afferent arteriole, and slower oscillations arising from а delay in the tubuloglomerular feedback. The paper investigates the intra- and inter-nephron interactions of these two modes. Besides full synchronization, both wavelet analyses of experimental data and numerical simulations of a detailed physiological model reveal the occurrence of а partial entrainment in which neighboring nephrons attain а state оf synchronization with respect to their slow dynamics, but the fast dynamics remain desynchronized.

Key words: 
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Acknowledgments: 
The research described in this publication was made possible to part by Award N. SR-006-X1 of the U.S.Civilian Research & Development Foundation for the Independent States of the Former Soviet Union (CRDF). A.P. acknowledges support from RF Minobr аnd CRDF (grant Y1-P-06-06). This work was also partly supported by INTAS grant (01-2061) and RFBR (01-02-16709).
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Received: 
05.09.2003
Accepted: 
10.10.2003
Available online: 
23.11.2023
Published: 
31.12.2003
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