ISSN 0869-6632 (Print)
ISSN 2542-1905 (Online)

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Rooy M. ., Novikov N. A., Zakharov D. G., Gutkin B. S. Interaction between PFC neural networks ultraslow fluctuations and brain oscillations. Izvestiya VUZ. Applied Nonlinear Dynamics, 2020, vol. 28, iss. 1, pp. 90-97. DOI: 10.18500/0869-6632-2020-28-1-90-97

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Interaction between PFC neural networks ultraslow fluctuations and brain oscillations

Rooy Marie , National Research University "Higher School of Economics"
Novikov N. A., National Research University "Higher School of Economics"
Zakharov Denis Gennadevich, National Research University "Higher School of Economics"
Gutkin Boris S, National Research University "Higher School of Economics"

Aim of the work was to study the influence of different brain rhythms (i.e. theta, beta, gamma ranges with frequencies from 5 to 80 Hz) on the ultraslow oscillations with frequency of 0.5 Hz and below, where high and low activity states alternate. Ultraslow oscillations are usually observed within neural activity in the human brain and in the prefrontal cortex in particular during rest. Ultraslow oscillations are considered to be generated by local cortical circuitry together with pulse-like inputs and neuronal noise. Structure of ultraslow oscillations shows specific statistics and their characteristics has been connected with cognitive abilities, such as working memory performance and capacity. Methods. In the study we used previously constructed computational model describing activity of a cortical circuit consisting of the populations of pyramidal cells and interneurons. This model was developed to mimic global input impinging on the local prefrontal cortex circuit from other cortical areas or subcortical structures. The model dynamics was studied numerically. Results. We found that frequency increase deferentially lengthens the up states and therefore increases stability of self-sustained activity with oscillations in the gamma band. Discussion. We argue that such effects would be beneficial to information processing and transfer in cortical networks with hierarchical inhibition


Acknowledgements. This work was supported by Russian Science Foundation, grant no. 17-11-01273.


1. Koukouli F., Rooy M., Changeux J.-P., and Maskos U. Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing. PNAS, 2016, vol. 113, no. 51, pp. 14823–14828.

2. Vyazovskiy V.V. and Harris K.D. Sleep and the single neuron: The role of global slow oscillations in individual cell rest. Nat Rev Neurosci, 2013, vol. 14, pp. 443–451.

3. Droste F. and Lindner B. Up-down-like background spiking can enhance neural information transmission. eNeuro, 2017, vol. 4. ENEURO.0282-17.2017.

4. Fell J., Axmacher N. The role of phase synchronization in memory processes. Nat Rev Neurosci, 2011, vol. 12, no. 2, pp. 105–118.

5. Jadi M., Polsky A., Schiller J., Mel B.W. Location-dependent effects of inhibition on local spiking in pyramidal neuron dendrites. PLoS Comput Biol, 2012, vol. 8, no. 6, e1002550.

6. Pi H.-J. et al. Cortical interneurons that specialize in disinhibitory control. Nature, 2013, vol. 503, pp. 521–52.

7. Papasavvas C.A., Wang Y., Trevelyan A.J., Kaiser M. Gain control through divisive inhibition prevents abrupt transition to chaos in a neural mass model. Phys Rev E Stat Nonlin Soft Matter Phys., 2015, vol. 9, no. 3, p. 032723.

8. Chance F.S., Abbott L.F. Divisive inhibition in recurrent networks. Network, 2000, vol. 11, no. 2, pp. 119–129.

9. Beierlein M., Gibson J.R., Connors B.W. Two Dynamically Distinct Inhibitory Networks in Layer 4 of the Neocortex. J Neurophysiol., 2003, vol. 90, pp. 2987–3000.

10. Pfeffer C.K., Xue M., He V., Huang Z.J., Scanziani M. Inhibition of inhibition in visual cortex: The logic of connections between molecularly distinct interneurons. Nature Neuroscience, 2013, vol. 16, pp. 1068–1076.

11. Rooy M., Koukouli F., Maskos U. and Gutkin B. Nicotinic modulation of hierarchal inhibitory control over prefrontal cortex resting state dynamics: Modeling of genetic modification and schizophrenia-related pathology, 2018. bioRxiv. 301051.