Для цитирования:
Sheinman M. Exact sequence matches in genomic studies [Шейнман М. Точные соответствия последовательностей в геномных исследованиях] // Известия вузов. ПНД. 2023. Т. 31, вып. 6. С. 739-756. DOI: 10.18500/0869-6632-003073, EDN: TVKYRH
Exact sequence matches in genomic studies
[Точные соответствия последовательностей в геномных исследованиях]
Цель этого обзора — рассмотреть использование точных соответствий геномных последовательностей в разных контекстах.
Методы. Здесь представлен явно не исчерпывающий список работ, в которых авторы добились интерпретируемых результатов, используя статистические данные точных соответствий разных геномных последовательностей или самосоответствий на одном геноме.
Результаты. Часто в геномных исследованиях разные геномные локусы обладают различными статистическими свойствами, в то время как их границы изначально не известны. В таких случаях рассмотрение статистических свойств точных соответствий является полезной альтернативой других методик, например основывающихся на разделении генома на произвольного размера участки — так называемые скользящие или нескользящие окна.
Заключение. Этот обзор демонстрирует, что анализ точных соответствий это не только вспомогательный шаг в выравнивании геномных последовательностей, но также выявляет биологические закономерности в различных контекстах.
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