For citation:
Gordleeva S. Y., Matrosov V. V., Kazantsev V. B. Calcium oscillations in astrocytes. Part 1 Astrocyte as generator of calcium oscillations. Izvestiya VUZ. Applied Nonlinear Dynamics, 2012, vol. 20, iss. 3, pp. 29-39. DOI: 10.18500/0869-6632-2012-20-3-29-39
Calcium oscillations in astrocytes. Part 1 Astrocyte as generator of calcium oscillations
Bifurcation mechanisms of oscillatory dynamics in a biophysical model of chemically excitable brain cells (astrocytes) were analyzed. In contrast to neuronal oscillators widely studied in nonlinear dynamics the astrocytes do not possess electrical excitability but capable to generate chemical oscillations which modulate neuronal signaling. Astrocyte dynamics is described by third-order system of ordinary differential equations derived from biophysical kinetics. We investigated bifurcation mechanisms of calcium oscillations in a single cell and stimulus-evoked dynamics of astrocytes under external pulse stimulation modeling neuron-astrocyte interaction.
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