ISSN 0869-6632 (Print)
ISSN 2542-1905 (Online)


For citation:

Gordleeva S. Y., Matrosov V. V., Kazantsev V. B. Calcium oscillations in astrocytes. Part 1 Astrocyte as generator of calcium oscillations. Izvestiya VUZ. Applied Nonlinear Dynamics, 2012, vol. 20, iss. 3, pp. 29-39. DOI: 10.18500/0869-6632-2012-20-3-29-39

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Russian
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Article
UDC: 
621.391.01

Calcium oscillations in astrocytes. Part 1 Astrocyte as generator of calcium oscillations

Autors: 
Gordleeva Susanna Yurevna, Lobachevsky State University of Nizhny Novgorod
Matrosov Valerij Vladimirovich, Lobachevsky State University of Nizhny Novgorod
Kazantsev Viktor Borisovich, Institute of Applied Physics of the Russian Academy of Sciences
Abstract: 

Bifurcation mechanisms of oscillatory dynamics in a biophysical model of chemically excitable brain cells (astrocytes) were analyzed. In contrast to neuronal oscillators widely studied in nonlinear dynamics the astrocytes do not possess electrical excitability but capable to generate chemical oscillations which modulate neuronal signaling. Astrocyte dynamics is described by third-order system of ordinary differential equations derived from biophysical kinetics. We investigated bifurcation mechanisms of calcium oscillations in a single cell and stimulus-evoked dynamics of astrocytes under external pulse stimulation modeling neuron-astrocyte interaction.

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Received: 
29.03.2012
Accepted: 
27.06.2012
Published: 
31.07.2012
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