Для цитирования:
Khlebtsov N. G., Bogatyrev V. A., Dykman L. A., Krasnov Y. M., Melnikov A. G. Optical properties of colloidal-gold bioconjugates [Хлебцов Н. Г., Богатырев В. А., Дыкман Л. А., Краснов Я. М., Мельников А. Г. Оптические свойства биоконъюгатов коллоидного золота] // Известия вузов. ПНД. 2002. Т. 10, вып. 3. С. 172-187. DOI: 10.18500/0869-6632-2002-10-3-172-187
Optical properties of colloidal-gold bioconjugates
[Оптические свойства биоконъюгатов коллоидного золота]
Обсуждаются оптические свойства единичных и агрегированных конъюгатов коллоидного золота, которые синтезируются при адсорбции биополимеров на поверхности золотых наночастиц. Для моделирования ослабления и рассеяния света подобными структурами использована обобщенная теория Ми для произвольной мультисферной конфигурации рассеивателей и метод дискретных диполей вместе с компьютерной моделью кластер-кластерной агрегации. В первой части статьи обсуждаются следующие вопросы: статистическое и ориентационное усреднение оптических наблюдаемых параметров; оптические эффекты, связанные с линейными цепочками наночастиц; влияние полимерного покрытия и межчастичного расстояния на оптические свойства агрегатов; моделирование кинетических изменений оптических свойств агрегированных золей, формируемых в процессе биоспецифического связывания конъюгатов; модификация мультипольного подхода для случая двухслойных мономеров. Во второй части статьи дается краткий обзор наших экспериментальных исследований по синтезу, теоретическому моделированию и практическому применению биомаркеров на основе коллоидного золота (включая биомедицинские приложения), и приводятся экспериментальные примеры оптического мониторинга биоспецифических взаимодействий на нанометровом масштабе.
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